Get 5 Carboxyl - terminal Domain Is a Novel Dimerization Motif
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چکیده
Background: The Get4/Get5 protein complex is a homodimer mediated by the Get5 carboxyl domain. Results: The Get5 homodimerization motif forms a structurally conserved helical domain allowing Get4/Get5 to adopt an extended solution conformation. Conclusion: Get5 homodimerization is mediated by a 35-residue sequence stabilized by a few conserved hydrophobic interactions. Significance: The Get5 carboxyl domain contains a novel example of a stable dimerization motif.
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تاریخ انتشار 2012